Independent research and innovation platform. Not an NHS organisation or NHS-endorsed service.
Opportunity Register

Prioritise what Sitora should test next, without confusing scale with recoverability.

The active medicines programme has three product lenses. The wider NHS register remains a research pipeline for future validation and expansion.

Current medicines lenses

Where an opportunity belongs determines how it is tested.

Medicine Loop

Continuity and reconciliation

Opportunities involving medication changes that fail to propagate or close across organisations.

WasteGuard

Avoidable supply

Opportunities involving cumulative oversupply, stock mismatch or repeat items that may not be required.

Resource Intelligence

Pathway resource

Opportunities involving route, formulation, preparation, workforce time, chair/bed use or unused medicines.

How ranking works

Scale, evidence, recoverability, readiness and measurability are scored separately. A high score prioritises investigation; it does not mean money is already available to save.

Highest current research priorities

Large signals with evidence, an actionable intervention and a way to verify change.

These may include medicines and wider NHS resource domains.

#1Hospital flowCapacity release
94

Delayed discharge after clinical readiness

Reduce avoidable days after discharge readiness by identifying the active constraint, assigning a named owner and escalating unresolved cross-system dependencies in real time.

Pilot readiness: Ready now

#2Elective careCapacity release
94

Missed outpatient appointments

Recover booked clinical capacity before it becomes idle by reducing cancellation friction, identifying high-risk appointments and filling released slots rapidly.

Pilot readiness: Ready now

#3Primary careCapacity release
93

Missed GP appointments

Recover primary-care capacity by identifying preventable non-attendance and making cancellation/rebooking and short-notice refill substantially easier.

Pilot readiness: Ready now

#4SurgeryCapacity release
91

Operating theatre lost minutes

Convert unexplained list-time loss into a minute-level operational dataset so repeated causes can be acted on and recovered time can be shown as additional usable surgical capacity.

Pilot readiness: Ready now

#5WorkforceCash-releasing
89

Avoidable agency staffing premium

Separate clinically necessary temporary staffing from recurrent avoidable premium use and target the specific roster, vacancy, retention or bank-fill causes.

Pilot readiness: Ready now

Full research pipeline

Every opportunity states what is known, what is uncertain and what would prove value.

Rank 1Hospital flowCapacity releaseEvidence: High

Delayed discharge after clinical readiness

94priority score

Observed signal

~30,000 patients per year staying at least 21 days beyond discharge-ready date; NHS England identified up to 500,000 bed days for release.

Opportunity

Reduce avoidable days after discharge readiness by identifying the active constraint, assigning a named owner and escalating unresolved cross-system dependencies in real time.

Operational owner

Acute trust + community provider + ICB + local authority

Intervention

Daily constraint coding, named ownership, care-transfer-hub escalation, early downstream activation and verified closure of the blocking dependency.

Scale98
Evidence95
Recoverability88
Readiness94
Measurability96

Pilot readiness: Ready now

Minimum data needed

  • Discharge-ready timestamp
  • Primary delay reason
  • Named dependency owner
  • Resolution timestamp
  • Destination/pathway
  • Additional bed days

What proves recovery

  • Bed days after readiness
  • Median delay by cause
  • Same-day discharge after readiness
  • Recurrent cause rate
  • Capacity actually reused

Safety / interpretation guardrails

  • No unsafe acceleration of discharge
  • Track readmission and safeguarding outcomes
  • Do not treat social-care constraints as provider failure
Source: NHS England urgent and emergency care / discharge guidance
Rank 2Elective careCapacity releaseEvidence: High

Missed outpatient appointments

94priority score

Observed signal

Millions of elective appointments are missed each year; NHS England has described DNAs as a major recoverable capacity problem and has published interventions that can reduce them quickly.

Opportunity

Recover booked clinical capacity before it becomes idle by reducing cancellation friction, identifying high-risk appointments and filling released slots rapidly.

Operational owner

Trust elective operations + specialty teams

Intervention

Two-way reminders, easy cancellation, short-notice waiting lists, risk-based reminder intensity and same-day backfill workflows.

Scale94
Evidence94
Recoverability92
Readiness96
Measurability95

Pilot readiness: Ready now

Minimum data needed

  • Appointment date
  • Booking lead time
  • Reminder delivery
  • Cancellation timing
  • DNA reason
  • Whether slot was backfilled

What proves recovery

  • DNA rate
  • Backfill rate
  • Additional patients seen
  • Unused clinician minutes
  • Waiting-time effect

Safety / interpretation guardrails

  • Do not penalise vulnerable patients
  • Monitor inequalities by deprivation, disability and language
  • Separate patient access barriers from behavioural assumptions
Source: NHS England Did Not Attends guidance
Rank 3Primary careCapacity releaseEvidence: High

Missed GP appointments

93priority score

Observed signal

16 million GP appointments were not attended in 2025, equivalent to 4.3% of appointments.

Opportunity

Recover primary-care capacity by identifying preventable non-attendance and making cancellation/rebooking and short-notice refill substantially easier.

Operational owner

Practices + PCNs + ICB primary care

Intervention

App/push reminders, one-tap cancellation, short-notice wait lists and targeted reminder intensity.

Scale90
Evidence97
Recoverability89
Readiness96
Measurability95

Pilot readiness: Ready now

Minimum data needed

  • Appointment type
  • Lead time
  • Reminder delivery
  • DNA
  • Cancellation timing
  • Backfill status

What proves recovery

  • DNA rate
  • Appointments backfilled
  • Clinician minutes reused
  • Waiting-time change

Safety / interpretation guardrails

  • Protect access for vulnerable groups
  • Do not use punitive cancellation rules
  • Analyse inequality effects
Source: NHS England, March 2026 GP appointment campaign
Rank 4SurgeryCapacity releaseEvidence: High

Operating theatre lost minutes

91priority score

Observed signal

Theatre utilisation has improved, but NHS England continues to identify theatre productivity and variation as a major source of further productivity gain.

Opportunity

Convert unexplained list-time loss into a minute-level operational dataset so repeated causes can be acted on and recovered time can be shown as additional usable surgical capacity.

Operational owner

Theatre operations + surgical divisions

Intervention

Common delay taxonomy, list-readiness checks, predictive scheduling, turnaround tracking and live escalation of recoverable gaps.

Scale92
Evidence90
Recoverability86
Readiness92
Measurability96

Pilot readiness: Ready now

Minimum data needed

  • Planned and actual start
  • Case duration
  • Turnaround
  • Cancellation reason
  • Staff/equipment readiness
  • List finish

What proves recovery

  • Touch-time utilisation
  • Late-start minutes
  • Turnaround minutes
  • Cases per list
  • Cancelled cases
  • Recovered minutes converted to activity

Safety / interpretation guardrails

  • Do not incentivise unsafe speed
  • Track overruns and staff fatigue
  • Case-mix adjust comparisons
Source: NHS England Productivity plan update, February 2026
Rank 5WorkforceCash-releasingEvidence: High

Avoidable agency staffing premium

89priority score

Observed signal

Agency spend fell from about £2.1bn in 2024/25 to about £1.2bn in 2025/26, proving that this cost base can change materially while leaving a substantial residual spend to understand.

Opportunity

Separate clinically necessary temporary staffing from recurrent avoidable premium use and target the specific roster, vacancy, retention or bank-fill causes.

Operational owner

Trust workforce + finance + divisional management

Intervention

Shift-level causal coding, bank-first escalation, roster analytics, hotspot recruitment and retention interventions.

Scale88
Evidence98
Recoverability72
Readiness94
Measurability97

Pilot readiness: Ready now

Minimum data needed

  • Agency shift
  • Premium vs bank/substantive
  • Reason agency used
  • Bank fill attempts
  • Vacancy age
  • Specialty

What proves recovery

  • Agency spend
  • Premium avoided
  • Bank fill rate
  • Unfilled shifts
  • Safety/quality indicators

Safety / interpretation guardrails

  • Do not create unsafe gaps
  • Track staff workload
  • Attribute savings only where premium use is actually displaced
Source: NHS England Month 12 financial position 2025/26
Rank 6Pharmacy / nursingMixedEvidence: High

Aseptic and injectable pathway redesign

88priority score

Observed signal

National modelling identified >4,000 WTE nursing capacity and >1 million bed days potentially releasable, alongside major aseptic productivity opportunity.

Opportunity

Move suitable medicines away from unnecessarily labour-intensive preparation and administration while reducing prepared-but-unused doses and cleanroom bottlenecks.

Operational owner

Chief pharmacist + aseptic service + clinical divisions

Intervention

Ready-to-administer conversion, dose banding, route optimisation, hub-and-spoke supply and prepared-dose waste measurement.

Scale93
Evidence91
Recoverability83
Readiness83
Measurability89

Pilot readiness: Ready with data

Minimum data needed

  • Product and presentation
  • Preparation time
  • Nursing administration time
  • Prepared-but-unused doses
  • Chair/bed time
  • Acquisition cost

What proves recovery

  • Nursing minutes released
  • Aseptic slots released
  • Unused doses
  • Chair/bed time released
  • Net pathway cost

Safety / interpretation guardrails

  • Clinical equivalence first
  • Supply resilience
  • Stability/storage controls
  • Do not count modelled capacity as realised until reused
Source: DHSC, Transforming NHS pharmacy aseptic services
Rank 7MedicinesMixedEvidence: Medium

Repeat medicines open loop

86priority score

Observed signal

NHS services continue to campaign against unnecessary repeat ordering, while digital repeat ordering has reached very large scale. The current national avoidable value is not measured robustly.

Opportunity

Close the gap between prescribing, dispensing and actual patient need so avoidable repeat supply can be prevented before dispensing rather than discovered as returned waste.

Operational owner

Primary care + community pharmacy + ICB medicines optimisation

Intervention

Patient stock confirmation, medication-change reconciliation, anomaly detection and pharmacist review before repeat items are authorised or dispensed.

Scale91
Evidence76
Recoverability91
Readiness84
Measurability86

Pilot readiness: Ready with data

Minimum data needed

  • Repeat item ordered
  • Last dispense date
  • Expected consumption
  • Patient-held stock
  • Recent medication changes
  • Hospital discharge changes

What proves recovery

  • Items safely not dispensed
  • Avoided acquisition cost
  • Pharmacist interventions
  • Emergency re-supply
  • Medication safety events

Safety / interpretation guardrails

  • Never auto-stop essential medication
  • Clinical/pharmacy review for exceptions
  • Monitor under-supply and adherence harms
Source: NHS England London, Only order what you need, March 2026
Rank 8Administration / digitalCash-releasingEvidence: Medium

Patient communications channel cost

86priority score

Observed signal

NHS England has identified substantial annual patient-communications expenditure while promoting lower-cost NHS App messaging and digital-by-default workflows.

Opportunity

Shift suitable communications from paid channels to secure digital delivery while protecting patients who require paper, phone or accessible formats.

Operational owner

Provider digital + communications + outpatient operations

Intervention

Channel-cost measurement, consent/availability routing, NHS App-first messaging and automatic fallback only where required.

Scale75
Evidence77
Recoverability90
Readiness94
Measurability98

Pilot readiness: Ready now

Minimum data needed

  • Message type
  • Channel
  • Unit cost
  • Delivery status
  • Digital eligibility
  • Fallback reason

What proves recovery

  • Paid messages avoided
  • Net communications cost
  • Delivery/read rate
  • Failure/fallback rate
  • Access complaints

Safety / interpretation guardrails

  • No digital exclusion
  • Accessible-format support
  • Clinical urgency must override cheapest channel
Source: NHS England performance/productivity reporting
Rank 9Medicines financeCost avoidanceEvidence: High

Provider medicines cost variation

83priority score

Observed signal

Provider drug spending has shown material adverse variance to plan, but the amount that is genuinely avoidable cannot be inferred from overspend alone.

Opportunity

Decompose drug-cost growth into price, volume, case mix, new therapies and potentially unwarranted variation before targeting procurement or prescribing change.

Operational owner

Chief pharmacist + finance + commissioning

Intervention

Price-volume-mix decomposition, biosimilar/brand analysis, procurement comparison and pathway-level prescribing variation review.

Scale95
Evidence93
Recoverability61
Readiness78
Measurability84

Pilot readiness: Ready with data

Minimum data needed

  • Drug spend by molecule
  • Volume
  • Unit price
  • Indication
  • Case mix
  • Contract price
  • Comparator providers

What proves recovery

  • Variance explained
  • Avoidable component
  • Unit-price change
  • Prescribing change
  • Clinical outcome safeguards

Safety / interpretation guardrails

  • Never equate overspend with waste
  • Protect access to clinically indicated innovation
  • Case-mix adjust comparisons
Source: NHS England financial performance reporting
Rank 10PreventionCost avoidanceEvidence: Developing

Preventable dental escalation in children

68priority score

Observed signal

Hospital treatment for preventable dental disease remains a substantial downstream burden, but the resource benefit of a new school/community detection pathway requires prospective evaluation.

Opportunity

Detect risk and visible disease earlier, complete referral loops and test whether earlier intervention reduces later urgent and hospital treatment without creating a new referral bottleneck.

Operational owner

ICB dental commissioning + schools + community dental services

Intervention

Structured periodic check, appropriate imaging where validated, parent communication and closed-loop referral to qualified dental review.

Scale76
Evidence66
Recoverability72
Readiness55
Measurability70

Pilot readiness: Needs design

Minimum data needed

  • Baseline oral-health risk
  • Screen finding
  • Referral
  • Attendance
  • Treatment completed
  • Later urgent/hospital activity

What proves recovery

  • Completed referrals
  • Earlier-stage treatment
  • Urgent attendance
  • Hospital extraction rate
  • Net pathway cost

Safety / interpretation guardrails

  • Screening is not diagnosis
  • Parental consent
  • Avoid overwhelming existing dental capacity
  • Clinical governance and device regulation
Source: Sitora research programme - requires prospective NHS pilot evidence
The register is a research pipeline. Sitora's current products are the governed mechanisms used to turn selected medicines opportunities into measurable local outcomes.